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Cerium doping of 45S5 bioactive glass improves redox potential and cellular bioactivity

  • 0Department of Orthodontics, Institute of Craniofacial Deformity, Yonsei University College of Dentistry, Seoul, 03722, Republic of Korea.
Scientific Reports +

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July 9, 2024

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July 9, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

This study synthesized cerium dioxide-doped bioglass (CBG) materials for hard tissue repair. CBG enhanced cellular activity and bone mineralization, showing potential for therapeutic applications.

Area Of Science

  • Biomaterials Science
  • Materials Chemistry
  • Biomedical Engineering

Background

  • 45S5 Bioglass (BG) is a silicate-based glass used in hard tissue therapy.
  • Nanoceria (CeO2) exhibits redox properties and enhances biological responses.
  • The optimal proportion of CeO2 doping in BG for cellular bioactivity is not well-established.

Purpose Of The Study

  • To synthesize and characterize a series of cerium dioxide-doped bioglass (CBG) materials.
  • To investigate the effect of varying CeO2 doping concentrations (1-12 wt.%) on the properties and bioactivity of BG.
  • To evaluate the potential of CBG for hard tissue therapeutic applications.

Main Methods

  • Synthesis of CBG series with increasing CeO2 content.
  • Characterization of glass structure, redox states of Ce, and antioxidant activity.
  • Assessment of mineralization capacity and cellular activity (proliferation, alkaline phosphatase activity, osteogenic gene expression) of CBG compared to BG.
  • Evaluation of biomineralization enhancement.

Main Results

  • CBG series maintained a stable glass network structure, similar to BG.
  • CBG exhibited antioxidant activity due to the Ce3+/Ce4+ redox states.
  • CBG promoted pre-osteoblastic cell proliferation, alkaline phosphatase activity, and osteogenic gene expression.
  • CBG enhanced biomineralization compared to BG.

Conclusions

  • The synthesized CBG series demonstrates preserved bioactivity and enhanced osteogenic properties.
  • The CeO2 doping effectively improved cellular responses and biomineralization.
  • CBG shows significant potential for applications in hard tissue regeneration and therapy.