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Prevalence of key potentially inappropriate drugs use in pediatrics: a cross-sectional study

Mariam Jihad Diab1, Sham ZainAlAbdin2, Salah Aburuz3

  • 1Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates.

BMC Pediatrics
|July 9, 2024
PubMed

Insights

Potentially inappropriate medication use in pediatric wards was 13.0%, with metoclopramide and tramadol being the most common. This highlights the need for safer drug alternatives for children.

Area of Science:

  • Pediatric Pharmacy
  • Clinical Pharmacology
  • Patient Safety

Background:

  • Pediatric drug prescribing is complex due to unique pharmacokinetics, leading to adverse drug reactions.
  • The Pediatric Pharmacy Association (PPA) identified 67 Key Potentially Inappropriate Drugs (KIDs) for pediatric use.

Purpose of the Study:

  • To determine the prevalence of potentially inappropriate medication (PIM) use in pediatric wards.
  • To assess PIM prevalence based on the PPA's KIDs list criteria.

Main Methods:

  • Retrospective observational study of pediatric patients from 2019-2021.
  • Matched KIDs list drugs to the hospital formulary, including 11 drugs for analysis.
  • Reviewed electronic patient files for PIM prescription appropriateness.

Main Results:

  • 13.0% of 3,166 pediatric patients received a PIM.
  • Metoclopramide (42.8%) and tramadol (37.6%) were the most frequently prescribed PIMs.
  • The study included 415 patients who received PIMs, with a mean age of 8.6 years.

Conclusions:

  • High prevalence of PIM use in pediatric wards necessitates further investigation.
  • Development of strategies and interventions is recommended to reduce PIM use in children.
  • Focus on identifying and implementing safer medication alternatives for pediatric patients.
Abstract

Keywords:
Inappropriate medication useKIDs listPediatricPediatric Pharmacy Association

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