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The Pattern of Anemia in Pediatric Solid Tumors Prior to and after Chemotherapy- A Retrospective Cohort Study

Tomal Barman Aron1, Sagor Kumar Roy2, Shuting Mao1

  • 1Department of Pediatrics, First Affiliated Hospital of Zhengzhou University, Henan, Zhengzhou, 450000, PR. China.

Current Cancer Drug Targets
|July 10, 2024
PubMed

Insights

Anemia is common in children with solid tumors, particularly neuroblastoma and hepatoblastoma. Bone marrow involvement and chemotherapy can worsen anemia, suggesting a need for targeted anemia therapy in pediatric cancer patients.

Area of Science:

  • Pediatric Oncology
  • Hematology

Background:

  • Solid pediatric tumors present unique challenges in diagnosis and treatment.
  • Anemia is a significant concern in children with these cancers.
  • Understanding anemia's causes is crucial for effective patient management.

Purpose of the Study:

  • To investigate the causes and manifestations of anemia in pediatric patients with solid tumors.
  • To evaluate blood parameters before and after chemotherapy in these patients.
  • To explore the relationship between anemia, serum ferritin, weight, and bone marrow metastasis.

Main Methods:

  • Retrospective cohort study of 235 pediatric solid tumor patients and 200 healthy controls.
  • Analysis of blood components (hemoglobin, RBC, WBC, platelets) pre- and post-chemotherapy.
  • Assessment of serum ferritin, weight, and bone marrow involvement in specific tumor types.

Main Results:

  • Observed various blood parameter derangements in patients with medulloblastoma, neuroblastoma, rhabdomyosarcoma, germ cell tumors, hepatoblastoma, and nephroblastoma.
  • Found a correlation between serum ferritin and weight in young neuroblastoma patients (p=0.022).
  • Confirmed bone marrow tumor involvement significantly correlates with decreased hemoglobin in neuroblastoma and hepatoblastoma (p=0.001).

Conclusions:

  • Anemia can be an early indicator for neuroblastoma, hepatoblastoma, and nephroblastoma.
  • Chemotherapy may exacerbate anemia in neuroblastoma and hepatoblastoma patients.
  • Anemia management and therapy are essential for pediatric cancer patients.
Abstract

Keywords:
Anemiaanemia therapy.bone marrow metastasishemoglobinnutritional deficiencypediatric solid tumors

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