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Long noncoding RNA MALAT1 in dermatologic disorders: a comprehensive review.
Dayanara Ruiz-Ojeda1,2, Carlos A Guzmán-Martín3,4, Rafael Bojalil5
1Posgrado en Medicina Interna, Hospital Central Sur de Alta Especialidad de Petróleos Mexicanos, Ciudad de México, C.P. 14140, México.
Biomarkers in Medicine
|July 10, 2024
Summary
Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) is a long noncoding RNA impacting skin biology and disease. This review explores MALAT1
Area of Science:
- Molecular biology
- Dermatology
- Genetics
Background:
- Dermatologic disorders involve complex molecular mechanisms.
- Long noncoding RNAs (lncRNAs) like MALAT1 regulate gene expression.
- MALAT1 influences inflammation, immunity, and signaling pathways relevant to skin.
Purpose of the Study:
- To review the role of MALAT1 in skin biology and pathology.
- To consolidate current knowledge on MALAT1's function in dermatologic conditions.
- To highlight potential diagnostic and therapeutic applications of MALAT1.
Main Methods:
- Literature review of studies on MALAT1 and dermatologic disorders.
- Analysis of MALAT1's molecular functions in skin.
- Synthesis of evidence regarding MALAT1 dysregulation in skin diseases.
Main Results:
- MALAT1 dysregulation is implicated in psoriasis, atopic dermatitis, and lupus erythematosus.
- MALAT1 influences key pathways in skin inflammation and immune response.
- The precise role of MALAT1 in these conditions requires further elucidation.
Conclusions:
- MALAT1 is a significant factor in dermatologic conditions.
- Understanding MALAT1's role offers potential for novel diagnostic tools.
- Targeting MALAT1 may present new therapeutic strategies for skin diseases.
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