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Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
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An Insight into Biodegradable Polymers and their Biomedical Applications for Wound Healing.

Tripti Halder1,2, Harshit Barot2, Bhavna Kumar1

  • 1Faculty of Pharmacy, DIT University, Dehradun, Uttarakhand, 248009, India.

Current Pharmaceutical Design
|July 10, 2024
PubMed
Summary
This summary is machine-generated.

Biodegradable polymers, including natural and synthetic types, effectively deliver therapeutic agents for enhanced wound healing. Advanced formulations and combinations of these polymers accelerate chronic wound repair processes.

Keywords:
Chitosanbiodegradable polymers.collagenhyaluronic acidpoly lactic co-glycolic acidwound healing

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Regenerative Medicine

Background:

  • Biodegradable polymers serve as effective carriers for drugs, bioactive molecules, and metals, enabling controlled substance release.
  • Advanced materials like hydrogels, scaffolds, and nanocomposites utilize these polymers for applications in cell proliferation, angiogenesis, hair growth, and wound management.

Purpose of the Study:

  • To review advancements in biodegradable polymers for wound healing applications.
  • To focus on specific natural and synthetic polymers and their formulations.
  • To discuss in vitro and in vivo studies evaluating polymer efficacy in wound healing.

Main Methods:

  • Examination of natural polymers (hyaluronic acid, collagen, chitosan, gelatin, alginate) and synthetic polymers (polylactic acid, polyglycolic acid, polylactic co-glycolic acid, PCA).
  • Analysis of various polymer formulations, including nanoparticle-loaded hydrogels, nanofibrous scaffolds, and nanocomposites.
  • Review of in vitro cell line studies and in vivo investigations on polymer applications in wound healing.

Main Results:

  • Biodegradable polymers demonstrate significant potential in promoting wound healing.
  • Modifications, combinations, and surface changes of polymers yield synergistic effects, overcoming individual limitations.
  • Polymeric mixes and scaffolds based on biodegradable polymers have notably accelerated wound healing.

Conclusions:

  • Biodegradable polymers are crucial in developing advanced wound healing materials.
  • Tailored formulations and combinations of natural and synthetic polymers enhance therapeutic outcomes.
  • Further research into polymeric materials promises accelerated healing for chronic wounds.