Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Translation01:31

Translation

141.8K
Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of...
141.8K
Leaky Scanning02:28

Leaky Scanning

5.1K
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.1K
Genomics02:02

Genomics

36.3K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
36.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Why in vivo models of disease remain indispensable.

Disease models & mechanisms·2026
Same author

The power of citation: giving credit where credit is due.

Disease models & mechanisms·2026
Same author

Mitochondrial heteroplasmy is a risk factor for the development of chronic lymphocytic leukemia.

Nature communications·2026
Same author

LncRNA CISTR-ACT regulates cell size in human and mouse by guiding FOSL2.

Nature communications·2025
Same author

Reversible compromise of physiological resilience by accumulation of heteroplasmic mtDNA mutations.

Science (New York, N.Y.)·2025
Same author

The NuRD component CHD3 promotes BMP signalling during cranial neural crest cell specification.

EMBO reports·2025
Same journal

Placental defects revealed by modelling PWS in mice.

Disease models & mechanisms·2026
Same journal

UBA1 knockdown dysregulates the levels of UBA1-sensitive proteins and impairs muscle function in Drosophila and mice.

Disease models & mechanisms·2026
Same journal

Electrical coupling between transplanted cardiomyocytes and host myocardium to prevent arrhythmia.

Disease models & mechanisms·2026
Same journal

Leucettinib-21 decreases dosage effects of DYRK1A in human trisomy 21 induced pluripotent stem cell-derived neural cells.

Disease models & mechanisms·2026
Same journal

Mesoscale maladaptation in disease organoids.

Disease models & mechanisms·2026
Same journal

A modeller's guide for biomedical discovery.

Disease models & mechanisms·2026
See all related articles

Related Experiment Video

Updated: Jun 21, 2025

Xenopus laevis as a Model to Identify Translation Impairment
10:24

Xenopus laevis as a Model to Identify Translation Impairment

Published on: September 27, 2015

10.7K

Translating multiscale research in rare disease

Kirsty M Hooper1, Monica J Justice2, Monkol Lek3

  • 1The Company of Biologists, Bidder Building, Station Road, Histon, Cambridge CB24 9LF, UK.

Disease Models & Mechanisms
|July 10, 2024
PubMed
Summary

No abstract available in PubMed .

More Related Videos

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
00:06

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

13.6K
In Vivo Modeling of the Morbid Human Genome using Danio rerio
12:31

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

20.7K

Related Experiment Videos

Last Updated: Jun 21, 2025

Xenopus laevis as a Model to Identify Translation Impairment
10:24

Xenopus laevis as a Model to Identify Translation Impairment

Published on: September 27, 2015

10.7K
In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
00:06

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

13.6K
In Vivo Modeling of the Morbid Human Genome using Danio rerio
12:31

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

20.7K