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Updated: Jun 21, 2025

Production and Detection of Reactive Oxygen Species ROS in Cancers
07:17

Production and Detection of Reactive Oxygen Species ROS in Cancers

Published on: November 21, 2011

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The role of reactive oxygen species in gastric cancer

Yuqi Wang1,2,3,4, Jingli Xu2,3,4, Zhenjie Fu2,3,4

  • 1College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.

Cancer Biology & Medicine
|July 10, 2024
PubMed

Insights

Reactive oxygen species (ROS) play a dual role in gastric cancer (GC) development and treatment. This review explores ROS sources, their impact on GC, and natural compounds for therapeutic strategies.

Area of Science:

  • Oncology
  • Biochemistry

Background:

  • Gastric cancer (GC) is a leading cause of cancer mortality globally.
  • Reactive oxygen species (ROS) are critical in cellular signaling and homeostasis.
  • ROS are implicated in the pathogenesis, progression, and therapeutic response of GC.

Purpose of the Study:

  • To review the multifaceted roles of ROS in gastric cancer.
  • To summarize ROS-inducing treatment modalities for GC.
  • To highlight natural compounds for ROS-targeted anti-GC therapies.

Main Methods:

  • Literature review of recent findings on ROS and GC.
  • Analysis of ROS sources and their bidirectional effects.
  • Evaluation of natural small molecules for anti-GC potential.

Main Results:

  • ROS exhibit complex regulatory effects on GC occurrence and development.
  • Various GC treatments leverage ROS induction.
  • Natural compounds show promise in modulating ROS for GC treatment.

Conclusions:

  • Modulating ROS levels presents a promising therapeutic strategy for gastric cancer.
  • Further research into natural compounds could accelerate clinical applications for GC treatment.
Keywords:
Gastric cancerROSantitumor therapynatural productspharmacologyreactive oxygen species

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