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  11. Serum Cystatin C, Monocyte/high-density Lipoprotein-c Ratio, And Uric Acid For The Diagnosis Of Coronary Heart Disease And Heart Failure

Serum cystatin C, monocyte/high-density lipoprotein-C ratio, and uric acid for the diagnosis of coronary heart disease and heart failure

Ming Li1, Da-Hao Yuan1, Zhi Yang1

  • 1Clinical Laboratory, Linquan County People's Hospital, Linquan 236400, Anhui Province, China.

World Journal of Clinical Cases
|July 10, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Serum cystatin C, monocyte/HDL cholesterol ratio, and uric acid show promise as novel biomarkers for diagnosing coronary heart disease and heart failure, aiding in patient risk stratification.

Area of Science:

  • Cardiology
  • Biomarker Discovery
  • Diagnostic Medicine

Background:

  • Coronary heart disease (CHD) and heart failure (HF) are leading global causes of mortality.
  • Current diagnostic methods for CHD and HF have limitations in sensitivity, specificity, and cost-effectiveness.
  • There is a critical need for simple, noninvasive, and reliable diagnostic biomarkers.

Purpose of the Study:

  • To evaluate the diagnostic utility of serum cystatin C (Cys-C), monocyte/high-density lipoprotein cholesterol ratio (MHR), and uric acid (UA).
  • To assess these biomarkers for the diagnosis of coronary heart disease (CHD) and heart failure (HF).

Main Methods:

  • Serum levels of Cys-C, MHR, and UA were measured in 80 patients with suspected CHD or HF.
  • Patients were categorized into four groups: CHD (n=20), HF (n=20), CHD + HF (n=20), and controls (n=20).
Keywords:
Coronary heart diseaseHeart failureMonocyte/high-density lipoprotein-C ratioRisk stratification

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  • Diagnostic performance was analyzed using receiver operating characteristic (ROC) curve analysis.

    • Main Results:

    • Significantly elevated serum levels of Cys-C, MHR, and UA were observed in CHD, HF, and CHD + HF groups compared to controls.
    • The CHD + HF group exhibited higher levels of these biomarkers than the CHD or HF groups individually.
    • ROC analysis indicated good diagnostic performance (AUC 0.78-0.93) for Cys-C, MHR, and UA in diagnosing CHD and HF.

    Conclusions:

    • Serum Cys-C, MHR, and UA are valuable biomarkers for diagnosing CHD, HF, and combined CHD + HF.
    • These biomarkers can assist in clinical decision-making and risk stratification for patients with heart conditions.
    • Further research may validate these findings for broader clinical application.
    Serum cystatin C
    Uric acid