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Related Concept Videos

Mitochondrial Membranes01:45

Mitochondrial Membranes

9.8K
A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
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Resting Potential Decay01:15

Resting Potential Decay

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The resting membrane potential of a neuron (-70mV) is sustained due to the selective ion permeability of the membrane. At the resting potential, the membrane is slightly permeable to ions like sodium (Na+) and chloride (Cl−) and highly permeable to potassium ions (K+). Differences in the ions' concentration inside the cell compared to the outside are maintained by membrane transport proteins like channels and pumps.
At rest, the K+ is the main ion that moves across the membrane...
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The Inner Mitochondrial Membrane01:28

The Inner Mitochondrial Membrane

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The inner mitochondrial membrane is the primary site of ATP synthesis. The inner membrane domain that forms a smooth layer adjacent to the outer membrane is called the inner boundary membrane. This domain contains membrane transporters that drive metabolites in and out of the mitochondria.  In contrast, the inner membrane network that invaginates into the matrix space is called the cristae membrane. This domain accounts for principle mitochondrial function as it accommodates the protein...
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  9. Predictive And Prognostic Markers
  11. Nk Cell Mitochondrial Membrane Potential-associated Model Predicts Outcomes In Critically Ill Patients With Covid-19.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Nk Cell Mitochondrial Membrane Potential-associated Model Predicts Outcomes In Critically Ill Patients With Covid-19.

Related Experiment Video

Isolation and Functional Analysis of Mitochondria from Cultured Cells and Mouse Tissue
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Isolation and Functional Analysis of Mitochondria from Cultured Cells and Mouse Tissue

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NK Cell Mitochondrial Membrane Potential-Associated Model Predicts Outcomes in Critically Ill Patients with COVID-19.

Qingqing Ma1,2, Guoju Luo1, Fei Wang1

  • 1Department of Clinical Laboratory, State Key Laboratory of Complex, Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People's Republic of China.

Journal of Inflammation Research
|July 10, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Natural killer (NK) cell mitochondrial membrane potential (MMP) can predict death in critically ill COVID-19 patients. Combining NK-cell MMP with D-dimer and fibrinogen levels improves mortality risk prediction.

Keywords:
COVID-19D-dimerNK cellfibrinogen

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Related Experiment Videos

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Area of Science:

  • Immunology
  • Critical Care Medicine
  • Biomarker Discovery

Background:

  • COVID-19 poses significant mortality risks, especially in critically ill patients.
  • Identifying reliable predictors of mortality is crucial for effective patient management.
  • Natural killer (NK) cell function, specifically mitochondrial membrane potential (MMP), is a potential area for investigation.

Purpose of the Study:

  • To investigate predictive models for mortality in critically ill COVID-19 patients using NK cell mitochondrial membrane potential (MMP).
  • To assess the correlation between NK-cell MMP and clinical indicators.
  • To develop a joint diagnostic model for predicting death risk.

Main Methods:

  • A cohort of 97 critically ill COVID-19 patients was studied.
mitochondrial membrane potential
mortality prediction
  • NK-cell MMP was measured using flow cytometry.
  • A joint diagnostic model was constructed integrating key indicators and evaluated using ROC curves.

    • Main Results:

    • Lower NK-cell MMP median fluorescence intensity (MFI) was observed in non-survivors (p<0.0001).
    • NK-cell MMP MFI positively correlated with D-dimer levels (r=0.56, p=0.0023).
    • Random forest analysis identified fibrinogen and NK-cell MMP MFI as key predictors; the combined model achieved an AUC of 0.94.

    Conclusions:

    • NK-cell MMP, combined with D-dimer and fibrinogen, shows potential for predicting mortality in critically ill COVID-19 patients.
    • This approach may aid in early risk stratification.
    • Improved risk assessment can lead to better patient care and outcomes.