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A Silicone Oil-Free Syringe Tailored for Intravitreal Injection of Biologics
Torleif T Gjølberg1,2,3, Heidrun E Lode1,2,3, Gustavo B Melo4,5
1Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Frontiers in Ophthalmology
|July 10, 2024
Summary
A novel, silicone oil-free syringe was developed for intravitreal injections (IVI). This new syringe ensures accurate dosing and safe storage of anti-VEGF biologics, offering a better alternative for retinal condition treatment.
Area of Science:
- Ophthalmology
- Biomaterials Science
- Pharmaceutical Technology
Background:
- Intravitreal injections (IVI) of anti-VEGF biologics revolutionized retinal disease management.
- Current IVI often use non-approved syringes, with silicone oil (SiO) lubrication causing potential vitreous deposition and patient discomfort.
Purpose of the Study:
- To develop and evaluate a novel, silicone oil-free syringe specifically designed for intravitreal injections.
- To assess the syringe's compatibility with common anti-VEGF agents and its safety profile.
Main Methods:
- Development of a novel syringe with no dead volume and high-accuracy dosing capabilities.
- Testing of pharmaceutical compounding and storage of bevacizumab, ranibizumab, and aflibercept for up to 30 days.
- Comparative safety analysis of SiO release versus SiO-lubricated syringes and prefilled alternatives.
Main Results:
- The new syringe enables accurate dosing and allows for compounding/storage of anti-VEGF drugs for 30 days without compromising efficacy.
- Demonstrated a favorable safety profile with significantly reduced SiO release compared to conventional syringes.
- Confirmed no compromise in functional binding or transport properties of stored biologics.
Conclusions:
- The developed silicone oil-free syringe is a safe and effective alternative for intravitreal injections.
- This innovation addresses the limitations of current IVI syringes, potentially improving patient outcomes and comfort.
- The syringe offers a promising solution for the accurate and safe delivery of anti-VEGF therapies.
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