Related Experiment Video
Updated: Jun 21, 2025

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
Published on: April 24, 2020
Problems in CSF and Ophthalmic Disease Research
Ryan Machiele1, Benjamin Jay Frankfort2, Hanspeter Esriel Killer3,4
1Department of Ophthalmology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Abstract:
There has been significant interest and progress in the understanding of cerebrospinal fluid pressure and its relationship to glaucoma and other ophthalmic diseases. However, just as every physiologic fluid pressure fluctuates, cerebrospinal fluid pressure (CSFP) is similarly dynamic. Coupling this with the difficulty in measuring the pressure, there are many obstacles in furthering this field of study. This review highlights some of the difficulties in CSFP research, including fluid compartmentalization, estimation equations, and pressure fluctuation. Keeping these limitations in mind will hopefully improve the quality and context of this burgeoning field.
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