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Updated: Jun 21, 2025

Imaging of In Situ Interferon Gamma Production in the Mouse Spleen following Listeria monocytogenes Infection
Published on: July 16, 2019
Q fever presenting as splenic infarct without endocarditis
Caitlin A Contag1, Lucy Studemeister2, Yael Bogler3
1Stanford University Department of Medicine, Divisions of Infectious Diseases and Critical Care Medicine, 300 Pasteur Dr. Lane-134, Palo Alto, CA, United States.
Abstract:
Q fever is frequently associated with the development of antiphospholipid antibodies though rarely causes thromboses. A 44-year-old man presented with diarrhea and fevers and was found to have a splenic infarct. Infectious work-up revealed acute Q fever as well as high anticardiolipin antibody titers. He was treated with doxycycline and hydroxychloroquine and suffered no further thromboembolic complications. The optimal management of thromboembolic complications is uncertain given the rarity of documented cases. However, the presence of these antibodies has been associated with increased risk of complications. Further investigation into the management of patients with Q fever associated hypercoagulability is needed.
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