Expression of Oxidative Stress and Inflammatory Indicators for Coronary Artery Disease in Kawasaki Disease

Area of Science:

• Pediatric Cardiology
• Inflammation Research
• Oxidative Stress Biomarkers

Background:

• Kawasaki disease (KD) can lead to coronary artery lesions (CALs).
• Understanding the role of oxidative stress (OS) and inflammation in CAL development is crucial for early detection.
• Identifying specific clinical relevance of OS and inflammation-associated targets in KD-related CALs is needed.

Purpose of the Study:

• To investigate the clinical relevance of oxidative stress and inflammation-associated targets in coronary artery lesions (CALs) in Kawasaki disease (KD).
• To develop a predictive model for early diagnosis of CALs in KD patients.

Main Methods:

• Clinical data from 455 KD patients were analyzed, divided into CAL and non-CAL (NCAL) groups.
• Regression analysis identified independent risk factors for CALs related to OS and inflammation.
• A predictive nomogram was constructed and validated using calibration and ROC curves.

Main Results:

• Elevated levels of CRP, IL-6, PLT count, ESR, ox-HDL, MDA, and PLR, and reduced HDL and SOD were observed in the CAL group.
• These markers, along with others, were identified as independent risk factors for CALs.
• The nomogram showed good predictive power (AUC 0.812 in development, 0.799 in validation).

Conclusions:

• A model incorporating 8 OS and inflammation-associated risk factors was developed for CALs in KD.
• This nomogram may serve as a valuable tool for the early diagnosis of CALs in Kawasaki disease.