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Transplantation for diabetic nephropathy.

J M Costa, B Haitas, A M Meyers

    South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
    |August 31, 1985
    PubMed
    Summary
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    Renal transplantation for diabetic nephropathy offers better outcomes than dialysis, especially with related living donors. While vision may improve, careful blood glucose management is crucial post-transplant.

    Area of Science:

    • Nephrology
    • Transplantation immunology
    • Diabetology

    Background:

    • End-stage diabetic nephropathy is a leading cause of end-stage renal disease (ESRD).
    • Renal transplantation is a potential treatment option for ESRD in diabetic patients.
    • Outcomes of renal transplantation in diabetic patients require further evaluation.

    Purpose of the Study:

    • To report the outcomes of renal transplantation in patients with end-stage diabetic nephropathy.
    • To compare the results of renal transplantation with dialysis and transplantation for non-diabetic renal failure.

    Main Methods:

    • Retrospective analysis of 17 patients with end-stage diabetic nephropathy who underwent renal transplantation.
    • Graft types included cadaver (CD) and related living donor (RLD) grafts.

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  • Patient and graft survival, renal function, visual acuity, peripheral vascular disease, and blood glucose control were assessed.

    • Main Results:

    • 11 out of 17 patients had good renal function post-transplantation.
    • Graft rejection occurred in 5 cases (4 acute), with 3 of these patients subsequently dying.
    • One patient died of heart failure despite functioning graft; visual acuity stabilized or improved, but peripheral vascular disease progressed.

    Conclusions:

    • Renal transplantation is a feasible and potentially preferred treatment for end-stage diabetic nephropathy.
    • Outcomes were superior to dialysis, particularly for RLD grafts.
    • Suboptimal blood glucose control necessitates closer attention post-transplantation.