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Revealing New Prospects: Antipsychotic Drugs Induces Anti-tumor Effects against Gastric Cancer through Inducing

Omolbanin Amjadi1, Akbar Hedayatizadeh-Omran2, Ehsan Zaboli3

  • 1Department of Medical Genetics, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran.

Current Cancer Drug Targets
|July 10, 2024
PubMed
Abstract

Insights

This study repurposed antipsychotic drugs, including cabergoline and dopamine, to inhibit gastric cancer (GC) cell growth. These findings suggest potential new therapies for GC by repurposing existing medications.

Area of Science:

  • Oncology
  • Pharmacology
  • Drug Repurposing

Background:

  • Gastric cancer (GC) is a leading cause of cancer mortality worldwide.
  • Understanding shared molecular mechanisms is crucial for developing novel targeted GC therapies.
  • This study utilized a drug repositioning strategy to identify potential GC drug candidates.

Purpose of the Study:

  • To investigate the efficacy of specific drugs as potential gastric cancer treatments.
  • To explore the drug repositioning approach for identifying novel therapeutic agents for GC.

Main Methods:

  • Human GC cell lines (AGS, MKN-45, KATO-III) were treated with dopamine, cabergoline, thioridazine, and entacapone.
  • Cytotoxic activity was assessed using the MTT assay.
  • Apoptosis, B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax), and Proliferating Cell Nuclear Antigen (PCNA) expression were evaluated via Annexin V/PI staining and qRT-PCR.

Main Results:

  • Dopamine, cabergoline, thioridazine, and entacapone demonstrated dose-dependent cytotoxic effects and induced apoptosis in AGS and KATO-III cells.
  • These drugs significantly decreased Bcl-2 and PCNA expression while increasing Bax expression in sensitive cell lines.
  • MKN-45 cells did not exhibit similar responses to the tested drugs.

Conclusions:

  • The antipsychotic drugs cabergoline, dopamine, thioridazine, and entacapone show potential in inhibiting gastric cancer cell growth.
  • These findings support the repurposing of these drugs as novel therapeutic agents for gastric cancer treatment.
Keywords:
Dopamineapoptosis.cabergolinedrug repurposingentacaponegastric cancerthioridazine

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