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The wavenumber linearisation without calibration device for spectral-domain optical coherence tomography
Xiupin Wu1, Wanrong Gao2, Zhiyuan Qiu2
1Department of Medical Instruments, Shanghai University of Medicine & Health Sciences, Shanghai, P. R. China.
Journal of Microscopy
|July 10, 2024
Summary
This study introduces a new method to improve image clarity in spectral-domain optical coherence tomography (SDOCT). The technique enhances resolution without needing calibration, offering superior performance for SDOCT imaging.
Area of Science:
- Biomedical Optics
- Medical Imaging Technology
- Optical Coherence Tomography
Background:
- Wavenumber nonlinearity in spectral-domain optical coherence tomography (SDOCT) causes blurred reconstructed images.
- Existing methods for correcting nonlinearity often require calibration devices.
Purpose of the Study:
- To present a novel wavenumber-linearisation method for SDOCT that does not require calibration devices.
- To improve image resolution and quality in SDOCT reconstructions.
Main Methods:
- A theoretical model was derived based on the phase difference between adjacent peak and valley points ().
- The method was validated using SDOCT data from a TiO2 phantom and zebrafish.
Main Results:
- The proposed wavenumber-linearisation method significantly reduces image blurring caused by nonlinearity.
- Resolution improvement of at least a factor of 2 compared to linear phase-based methods.
- Resolution improvement of nearly half compared to polynomial fitting methods.
Conclusions:
- The developed method effectively corrects wavenumber nonlinearity in SDOCT without calibration.
- This technique offers superior performance, enhancing image resolution and quality for SDOCT applications.
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