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Updated: Jun 21, 2025

On-Chip Endothelial Inflammatory Phenotyping
Published on: July 21, 2012
ECM Microenvironment in Vascular Homeostasis: New Targets for Atherosclerosis
Lu Zhang1, Qianqian Feng2, Wei Kong2
1Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao, China.
Abstract:
Alterations in vascular extracellular matrix (ECM) components, interactions, and mechanical properties influence both the formation and stability of atherosclerotic plaques. This review discusses the contribution of the ECM microenvironment in vascular homeostasis and remodeling in atherosclerosis, highlighting Cartilage oligomeric matrix protein (COMP) and its degrading enzyme ADAMTS7 as examples, and proposes potential avenues for future research aimed at identifying novel therapeutic targets for atherosclerosis based on the ECM microenvironment.
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