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Min Hyung Ryu1,2,3, Illiassou Hamidou Soumana1,2, Denise J Wooding1,2

  • 1Air Pollution Exposure Lab, Division of Respiratory Medicine, University of British Columbia, British Columbia, Canada.

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The human respiratory tract, comprising the upper and lower segments, serves as a critical interface with the external environment. The upper respiratory tract (URT)—including the nostrils, sinuses, pharynx, and oropharynx—is heavily colonized by microbes, while the lower respiratory tract (LRT), composed of the larynx, trachea, bronchi, and lungs, was long thought to be sterile. However, recent molecular studies have revealed that the lungs are not devoid of microbes but act more like...

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