Related Experiment Video

Updated: Jun 21, 2025

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

19.7K

Estimating the prevalence and clinical causality of obstructive sleep apnea in paediatric narcolepsy patients

Chaofan Geng1, Chen Chen2,3

  • 1Department of Neurology & Innovation Center for Neurological Disorders, Xuanwu Hospital, National Center for Neurological Disorders, Capital Medical University, Beijing, China.

Sleep & Breathing = Schlaf & Atmung
|July 10, 2024
PubMed

Insights

Children with narcolepsy have a significantly higher risk of obstructive sleep apnea (OSA). This study suggests a potential causal link, emphasizing the need for OSA screening in pediatric narcolepsy patients.

Area of Science:

  • Sleep Medicine
  • Genetics
  • Pediatrics

Background:

  • Paediatric narcolepsy may share risk factors with obstructive sleep apnea (OSA).
  • The co-occurrence of OSA can lead to the underdiagnosis of narcolepsy in children.
  • Investigating the relationship between paediatric narcolepsy and OSA is crucial.

Purpose of the Study:

  • To determine the prevalence of OSA in paediatric narcolepsy.
  • To explore the potential causal relationship between narcolepsy and OSA in children.
  • To highlight the importance of OSA screening in paediatric narcolepsy.

Main Methods:

  • A case-control study design was utilized.
  • Two-sample Mendelian randomization (MR) analysis was performed.
  • Statistical analyses included Odds Ratios (OR) and inverse-variance weighted (IVW) models.

Main Results:

  • Paediatric narcolepsy patients showed a significantly increased risk of OSA (OR: 4.87).
  • Mendelian randomization suggested a potential causal link between narcolepsy and OSA (IVW OR: 4.671).
  • Sensitivity analyses confirmed the robustness of the findings.

Conclusions:

  • There is an elevated prevalence and genetic susceptibility to OSA in paediatric narcolepsy.
  • Clinical screening for OSA is recommended for children diagnosed with narcolepsy.
  • Further research is needed to elucidate pathogenic mechanisms and develop targeted treatments.
Abstract

Keywords:
Causal relationshipsMendelian randomizationNarcolepsyObstructive sleep apneaPrevalence

More Related Videos

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach04:53

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach

Published on: October 18, 2024

755
Author Spotlight: Utilizing Traditional Chinese Acupuncture of the Ear to Improve Sleep Disorders05:34

Author Spotlight: Utilizing Traditional Chinese Acupuncture of the Ear to Improve Sleep Disorders

Published on: August 18, 2023

2.2K

Related Concept Videos

Sleep Apnea01:21

Sleep Apnea

Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
140
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.3K
Narcolepsy01:07

Narcolepsy

Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
101
Other Pulmonary Disorders01:17

Other Pulmonary Disorders

Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
815
Nightmares and Night Terrors01:18

Nightmares and Night Terrors

Nightmares and night terrors represent two distinct types of sleep disturbances that differ in timing, characteristics, and the sleeper's recall of the event. Nightmares are vivid, disturbing dreams that usually awaken the sleeper from REM sleep, a stage of sleep where brain activity is high, and dreams are most frequent. Upon awakening, individuals often have detailed recollections of their nightmares, which can include themes of threats to survival, security, or self-esteem.
Nightmares...
82
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
164