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Updated: Jun 21, 2025

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes
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A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes

Published on: September 15, 2018

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Emerging therapies for refractory hypercholesterolemia: a narrative review

Agnieszka Pawlos1, Etienne Khoury2, Daniel Gaudet2

  • 1Department of Internal Diseases & Clinical Pharmacology, Laboratory of Tissue Immunopharmacology, Medical University of Lodz, Kniaziewicza 1/5, 91-347, Lodz, Poland.

Future Cardiology
|July 10, 2024
PubMed
Summary

Refractory hypercholesterolemia (RH) is a condition where patients don't reach cholesterol goals despite treatment. This review explores RH therapies, emphasizing low-density lipoprotein receptor (LDLR) activity for personalized treatment strategies.

Keywords:
LDL receptor-independent pathwayscardiovascular diseasegene therapiesrefractory hypercholesterolemia

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