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Metabolic Responses to Redox Stress in Vascular Cells
Wusheng Xiao1,2, Laurel Y Lee1, Joseph Loscalzo1
1Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Antioxidants & Redox Signaling
|July 10, 2024
Summary
Vascular cells adapt metabolism to maintain redox balance, crucial for preventing vascular disease. Understanding metabolic reprogramming under redox stress is key to developing new therapies.
Area of Science:
- Vascular biology
- Cellular metabolism
- Redox signaling
Background:
- Redox stress is a major driver of vascular diseases.
- Vascular cells require metabolic adaptability to maintain redox homeostasis.
- Metabolic heterogeneity exists among vascular cells, influencing disease progression.
Purpose of the Study:
- To explore the intricate relationship between redox stress and metabolic reprogramming in vascular cells.
- To highlight the need for a deeper understanding of metabolic pathway connectivity and regulation.
- To emphasize the importance of studying cross-regulatory mechanisms between redox and metabolic systems.
Main Methods:
- Single-cell technologies
- Multiomic studies
- Analysis of metabolic flux and cellular responses to stress
Main Results:
- Redox stress induces significant metabolic reprogramming in vascular cells.
- Intracellular L-2-hydroxyglutarate accumulation protects pulmonary vascular cells from hypoxic reductive stress.
- Metabolic adaptability is essential for vascular cell survival and function under stress.
Conclusions:
- Further research is needed to elucidate the complex wiring of metabolic pathways in vascular cells.
- Understanding the sensing and regulation of metabolic pathways by redox perturbations is critical.
- Integrating dynamic multiomic data is essential for a comprehensive view of redox-metabolic crosstalk.
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