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Using the High-Entropy Approach to Obtain Multimetal Oxide Nanozymes: Library Synthesis, In Silico
Thuong Phan-Xuan1,2, Simon Schweidler3, Steffen Hirte1,2
1Department of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria.
ACS Nano
|July 10, 2024
Summary
High-entropy nanomaterials with peroxidase-like activity were synthesized for biosensing. Compositional complexity enhanced catalytic performance, offering a new design strategy for nanozymes.
Area of Science:
- Materials Science
- Nanotechnology
- Biochemistry
Background:
- High-entropy nanomaterials offer unique properties for industrial applications.
- Peroxidases are metalloenzymes crucial for catalyzing hydrogen peroxide decomposition.
Purpose of the Study:
- To develop multimetal oxide nanozymes with peroxidase-like activity using a high-entropy approach.
- To explore their application as sensors in ex vivo bioassays.
Main Methods:
- Synthesized a library of 81 materials via coprecipitation.
- Substituted A and B sites of magnetite structure with up to six different cations (Cu/Fe/Zn/Mg/Mn/Cr).
- Developed a generalized linear model to correlate composition with catalytic activity.
Main Results:
- Increased compositional complexity enhanced nanozyme catalytic performance.
- Single element substitutions significantly reduced peroxidase-like activity.
- Identified synergistic and antagonistic binary element interactions.
Conclusions:
- A mean interaction effect parameter strongly correlated with catalytic activity.
- This provides a valuable tool for designing high-entropy-inspired nanozymes.
- Developed nanozymes show promise for ex vivo bioassay sensing applications.
