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Related Concept Videos

Hematopoiesis01:21

Hematopoiesis

5.2K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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Overview of Hematopoiesis01:20

Overview of Hematopoiesis

3.9K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
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Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Lineage Commitment01:21

Lineage Commitment

3.0K
Commitment is the  process whereby stem cells:
3.0K
Production of Formed Elements01:34

Production of Formed Elements

1.4K
Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
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A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
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New frameworks for hematopoiesis derived from single-cell genomics.

Ksenia Safina1,2,3,4, Peter van Galen1,2,3,4

  • 1Division of Hematology, Brigham and Women's Hospital, Boston, MA.

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Single-cell genomics reveals intermediate states in hematopoietic stem cell differentiation. Understanding these dynamics can help extend healthy blood formation and prevent disease.

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A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
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Simultaneous Assessment of Kinship, Division Number, and Phenotype via Flow Cytometry for Hematopoietic Stem and Progenitor Cells
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Area of Science:

  • Hematopoiesis research
  • Stem cell biology
  • Genomics

Background:

  • Single-cell genomics has advanced the study of blood cell formation.
  • It has revealed cell population heterogeneity and continuous differentiation pathways.
  • Intermediate states in stem and progenitor cells structure these dynamics.

Purpose of the Study:

  • To discuss how model systems quantify lineage bias.
  • To explore how stress impacts differentiation and plasticity.
  • To offer a perspective on the current hematopoiesis model.

Main Methods:

  • Analysis of single-cell genomics data.
  • Utilizing innovative model systems to quantify lineage bias.
  • Comparing stress-induced differentiation with native hematopoiesis.

Main Results:

  • Identification of intermediate "attractor" states in stem and progenitor populations.
  • Quantification of lineage bias using novel model systems.
  • Demonstration that stress accelerates differentiation, reducing fate plasticity.

Conclusions:

  • A precise understanding of hematopoiesis is crucial.
  • This knowledge can inform strategies to promote healthy blood formation.
  • It can also guide the prevention and treatment of blood-related diseases.