The role of extracellular vesicles in pyroptosis-mediated infectious and non-infectious diseases
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Extracellular vesicles (EVs) are emerging as key regulators of pyroptosis, a cell death process implicated in various diseases. This review explores how EVs influence disease progression by modulating pyroptosis, highlighting potential therapeutic targets.
Area Of Science
- Cellular biology
- Immunology
- Pathophysiology
Background
- Pyroptosis is a lytic, pro-inflammatory cell death pathway crucial in disease.
- Extracellular vesicles (EVs) act as intercellular messengers, mediating communication between cells.
- Emerging evidence indicates EVs play significant roles in disease by influencing pyroptosis.
Purpose Of The Study
- To review recent findings on how EVs regulate pyroptosis.
- To examine the role of EVs in disease progression, both infectious and non-infectious.
- To highlight the therapeutic potential of understanding EV-mediated pyroptosis.
Main Methods
- Literature review of recent research on EVs and pyroptosis.
- Analysis of studies investigating EV-mediated pyroptosis in various disease models.
- Synthesis of current knowledge on the mechanisms of EV-pyroptosis interaction.
Main Results
- EVs, derived from both host and bacteria, can manipulate pyroptosis.
- EVs influence disease progression through pyroptosis regulation in both infectious and non-infectious conditions.
- Specific characteristics and activities of EVs in pyroptosis are being elucidated.
Conclusions
- EVs are versatile mediators in pyroptosis, impacting diverse pathophysiological processes.
- Understanding EV-pyroptosis interactions offers novel insights into disease mechanisms.
- Targeting EV-mediated pyroptosis may lead to new therapeutic strategies for various diseases.
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
Related Concept Videos
The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or immature dendritic cells. Non-professional phagocytes such as epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes.
Normal cells contain receptors that prevent them from being recognized...
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...