Related Experiment Video
Updated: Jun 21, 2025

A Strategy for the Study of IL-9-Producing Lymphoid Cells in the Nippostrongylus brasiliensis Infection Model
Published on: March 3, 2023
The pros and confs of IL-18 activation
Danielle M Clancy1, Julie Andries1, Savvas N Savvides1
1Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium; Unit for Structural Biology, VIB-UGent Center for Inflammation Research, Ghent, Belgium.
Abstract:
Interleukin-1 (IL-1) family cytokines are key immunological regulators that achieve their signaling prowess after post-translational proteolytic processing. In this issue of Immunity, Dong et al. reveal the structural consequences of this process on proinflammatory IL-18, demonstrating that pro-IL-18 and mature IL-18 are structurally distinct.
Related Concept Videos
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
T Cell Activation and Clonal Selection
Naive T cells that have not yet encountered an antigen express two primary CD...

