Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Methods of reducing fever01:22

Methods of reducing fever

658
The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
658
Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

119
Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
119
Increased Body Temperature01:25

Increased Body Temperature

652
A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
652
Mechanisms of Heat Transfer01:14

Mechanisms of Heat Transfer

312
Heat transfer between the human body and its environment occurs through four main mechanisms: conduction, convection, radiation, and evaporation.
Conduction, accounting for approximately 3% of body heat loss at rest, is the process of exchanging heat between molecules of two materials in direct contact. This can result in both heat loss and gain. For instance, when the body is submerged in water, which conducts heat 20 times more effectively than air, it can either lose or gain significant...
312
Mechanism of heat transfer01:19

Mechanism of heat transfer

1.2K
Understanding heat transfer mechanisms is essential for understanding how our bodies maintain balance in different environmental conditions. When the environment is thermoneutral, the body is in a state of balance, neither using nor releasing energy to maintain its core temperature. However, when the environment is not thermoneutral, the body employs four heat transfer mechanisms to maintain homeostasis: conduction, convection, evaporation, and radiation. These mechanisms facilitate heat...
1.2K
Types of Fever01:25

Types of Fever

362
Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
Here are the different types of fever:
362

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting Pyruvate Kinase M2: Signal Transduction Pathways and Exploration of Cancer Therapeutic Strategies.

The AAPS journal·2026
Same author

Natural Products Beyond Inhibition: A Mechanistic Framework Spanning Pockets, Interfaces, and Kinetic Barriers.

Molecules (Basel, Switzerland)·2026
Same author

Alleviation of diabetic cardiomyopathy via preventing VCAM1-positive cells from senescence by engineered nanovesicles.

Journal of nanobiotechnology·2026
Same author

Unraveling the pleiotropic effects of CCR2-dependent signal transduction in fibrosis development.

Theranostics·2026
Same author

Novel <i>VRK1</i> Variants and a Founder Effect in Axonal Polyneuropathy.

Neurology. Genetics·2026
Same author

IGF-1 attenuates high fat diet-elicited cardiomyopathy via arachidylcarnitine-dependent suppression of ferroptosis and mitochondrial dysfunction.

European journal of pharmacology·2026

Related Experiment Video

Updated: Jun 21, 2025

A Preclinical Model of Exertional Heat Stroke in Mice
08:22

A Preclinical Model of Exertional Heat Stroke in Mice

Published on: July 1, 2021

3.7K

Heat stroke: Pathogenesis, diagnosis, and current treatment.

Zhe Zhang1, Xiaopeng Wu1, Zheng Zou2

  • 1Xi'an Key Laboratory of Innovative Drug Research for Heart Failure, Northwest University First Hospital, Faculty of Life Sciences and Medicine, Northwest University, 229 Taibai North Road, Xi'an, 710069, China.

Ageing Research Reviews
|July 10, 2024
PubMed
Summary

Rising heat-related illnesses, including severe heat stroke, are linked to environmental factors. This review explores heat stroke

Keywords:
Disseminated intravascular coagulationHeat strokeHeat-related illnessesMultiple organ dysfunction syndrome

More Related Videos

Prevention of Heat Stress Adverse Effects in Rats by Bacillus subtilis Strain
07:57

Prevention of Heat Stress Adverse Effects in Rats by Bacillus subtilis Strain

Published on: July 11, 2016

7.6K
Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management
06:43

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management

Published on: November 21, 2017

24.3K

Related Experiment Videos

Last Updated: Jun 21, 2025

A Preclinical Model of Exertional Heat Stroke in Mice
08:22

A Preclinical Model of Exertional Heat Stroke in Mice

Published on: July 1, 2021

3.7K
Prevention of Heat Stress Adverse Effects in Rats by Bacillus subtilis Strain
07:57

Prevention of Heat Stress Adverse Effects in Rats by Bacillus subtilis Strain

Published on: July 11, 2016

7.6K
Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management
06:43

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management

Published on: November 21, 2017

24.3K

Area of Science:

  • Environmental Health
  • Pathophysiology
  • Pharmacology

Background:

  • Increasing incidence of heat-related illnesses linked to climate change and air pollution.
  • Heat stroke, a severe heat-related illness, is characterized by high core body temperature (>40°C) and central nervous system dysfunction.
  • The pathogenesis of heat stroke involves complex mechanisms like inflammation, oxidative stress, cell death, and coagulation issues.

Purpose of the Study:

  • To consolidate recent research on the pathophysiology and pathogenesis of heat stroke.
  • To focus on the molecular mechanisms underlying heat stroke.
  • To review current treatment strategies and preclinical drugs for heat stroke.

Main Methods:

  • Literature review of recent research on heat stroke.
  • Analysis of molecular mechanisms involved in heat stroke pathogenesis.
  • Compilation of data on therapeutic strategies and drug development for heat stroke.

Main Results:

  • Detailed overview of the complex molecular pathways contributing to heat stroke.
  • Identification of key inflammatory, oxidative stress, cell death, and coagulation pathways.
  • Summary of preclinical drug candidates and therapeutic approaches.

Conclusions:

  • Heat stroke pathogenesis is multifaceted, involving interconnected molecular processes.
  • Further research is needed to fully elucidate these mechanisms for effective treatment.
  • Developing novel therapeutic strategies and drugs is crucial to reduce heat stroke mortality.