Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Water Intake01:25

Regulation of Water Intake

492
Osmolality refers to the number of solute particles per kilogram of solvent in a solution. Plasma osmolality specifically indicates the total number of solute particles per kilogram of water in blood plasma. This value reflects the body's hydration status and is tightly regulated through mechanisms controlling water intake and output. While water consumption is a conscious decision, the body has intrinsic regulatory systems to maintain fluid balance. Dehydration, a state of water deficit...
492
Primary Motives: Hunger and Thirst01:25

Primary Motives: Hunger and Thirst

174
Hunger and thirst are fundamental physiological drives crucial for maintaining homeostasis and ensuring the survival of both humans and animals. These drives are regulated through complex interactions between the brain, hormones, and sensory receptors.
Hunger arises when the brain detects changes in the body's nutrient levels, including glucose, lipids, amino acids, and hormones such as ghrelin and leptin. The hypothalamus plays a central role in hunger regulation. The lateral hypothalamus...
174
Major Somatic Sensory Pathways01:28

Major Somatic Sensory Pathways

939
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
939
Regulation of Food Intake01:30

Regulation of Food Intake

216
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
216
Neural Regulation01:37

Neural Regulation

39.3K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.3K
Salivary Glands and Saliva01:23

Salivary Glands and Saliva

586
The salivary glands, of which there are three pairs known as the parotid, submandibular, and sublingual glands, play a crucial role in maintaining oral health and initiating the digestive process. Positioned near the ears, beneath the masseter muscle, the parotid glands secrete saliva into the oral cavity through the parotid duct of Stensen. Meanwhile, the submandibular glands, located on the floor of the mouth, secrete saliva through channels named submandibular ducts. The sublingual glands,...
586

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Asprosin-PTPRD endocrine resistance links brain dysfunction and systemic wasting in Alzheimer's disease.

Research square·2026
Same author

Shared neural geometries for bilingual semantic representations in human hippocampal neurons.

Cell·2026
Same author

Harvard's second fukushima field trip course: an overview.

Fukushima journal of medical science·2026
Same author

Immune Aging is an Independent Risk Factor for Cardiovascular Disease.

bioRxiv : the preprint server for biology·2026
Same author

Detecting Features of Interpersonal Difficulties in First-Person Accounts of Schizophrenia; Automated Linguistic and Network Analyses.

Schizophrenia bulletin open·2026
Same author

Human and mouse cerebellar inhibitory circuits in dystonic crisis and their modulation with therapeutic stimulation.

bioRxiv : the preprint server for biology·2026
Same journal

Noninvasive decoding of typed sentences from human brain activity.

Nature neuroscience·2026
Same journal

Striatal control of amygdalar acetylcholine release during salience-associated processing.

Nature neuroscience·2026
Same journal

Mitochondrial stress response drives microglial senescence.

Nature neuroscience·2026
Same journal

Conditioned accumbal dopamine transients forecast individual preference for drug versus natural rewards and compulsive behavior.

Nature neuroscience·2026
Same journal

The mitochondrial unfolded protein response in human microglia disrupts neuronal-glial communication and promotes senescence.

Nature neuroscience·2026
Same journal

Interpretable abstractions of artificial neural networks predict behavior and neural activity during human information gathering.

Nature neuroscience·2026
See all related articles

Related Experiment Video

Updated: Jun 21, 2025

Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation
07:29

Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation

Published on: December 29, 2023

639

The cerebellum modulates thirst.

Ila Mishra1,2, Bing Feng3, Bijoya Basu4

  • 1Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

Nature Neuroscience
|July 10, 2024
PubMed
Summary
This summary is machine-generated.

The cerebellum regulates thirst by activating Purkinje neurons with the hormone asprosin. This discovery reveals the cerebellum

More Related Videos

In Vivo Calcium Imaging of Taste-Induced Neural Responses in Adult Drosophila
06:30

In Vivo Calcium Imaging of Taste-Induced Neural Responses in Adult Drosophila

Published on: March 7, 2025

452
Modulating Cognition Using Transcranial Direct Current Stimulation of the Cerebellum
11:47

Modulating Cognition Using Transcranial Direct Current Stimulation of the Cerebellum

Published on: February 15, 2015

28.6K

Related Experiment Videos

Last Updated: Jun 21, 2025

Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation
07:29

Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation

Published on: December 29, 2023

639
In Vivo Calcium Imaging of Taste-Induced Neural Responses in Adult Drosophila
06:30

In Vivo Calcium Imaging of Taste-Induced Neural Responses in Adult Drosophila

Published on: March 7, 2025

452
Modulating Cognition Using Transcranial Direct Current Stimulation of the Cerebellum
11:47

Modulating Cognition Using Transcranial Direct Current Stimulation of the Cerebellum

Published on: February 15, 2015

28.6K

Area of Science:

  • Neuroscience
  • Endocrinology
  • Physiology

Background:

  • The cerebellum, traditionally viewed as a motor control center, is increasingly recognized for its roles in non-motor functions.
  • Emerging evidence suggests cerebellar involvement in cognition, emotion, and autonomic regulation.

Purpose of the Study:

  • To investigate the role of cerebellar Purkinje neurons in thirst regulation.
  • To identify the molecular mechanisms underlying asprosin-mediated thirst signaling in the cerebellum.

Main Methods:

  • Utilized optogenetic and chemogenetic techniques in mice to manipulate Purkinje neuron activity.
  • Investigated the effects of asprosin hormone and its receptor (Ptprd) on water intake.
  • Assessed motor learning and coordination to differentiate cerebellar functions.

Main Results:

  • Cerebellar Purkinje neurons are activated by asprosin, leading to increased thirst and water drinking.
  • Deletion of the asprosin receptor (Ptprd) in Purkinje neurons reduced water intake and abolished asprosin's dipsogenic effect.
  • Cerebellar motor functions remained unaffected, indicating distinct roles for Purkinje neurons.

Conclusions:

  • The cerebellum functions as a critical thirst-modulating brain region.
  • Asprosin-Purkinje neuron signaling represents a novel pathway for thirst regulation.
  • The asprosin-Ptprd pathway is a potential therapeutic target for thirst disorders.