Understand the Stabilization Engineering of Ascorbic Acid, Mapping the Scheme for Stabilization, and Advancement

Area of Science:

• Cosmetic Science
• Pharmaceutical Formulation
• Dermatology

Background:

• Vitamin C (ascorbic acid) is a popular cosmetic ingredient for skin rejuvenation.
• Its instability and degradation in formulations limit its efficacy.
• Developing stable vitamin C formulations is crucial for cosmetic applications.

Purpose of the Study:

• To develop and optimize stable topical formulations of vitamin C.
• To investigate the impact of specific ingredients on vitamin C stability.
• To evaluate the performance and stability of the optimized formulations.

Main Methods:

• Utilized Design of Experiments (DoE) for formulation optimization.
• Adapted pharmacopeial analytical methods for vitamin C assay and related substances.
• Conducted in-vitro release studies and stability testing per ICH guidelines.

Main Results:

• Citric acid and tartaric acid significantly impacted formulation stability.
• Optimized formulations demonstrated satisfactory evaluation parameters and consistent in-vitro release.
• Stability studies confirmed product integrity under various storage conditions.

Conclusions:

• A stable topical vitamin C formulation was successfully developed.
• The combination of citric acid, tartaric acid, and tocopherol effectively reduced vitamin C degradation.
• The optimized formulation ensures consistent release and skin permeation of ascorbic acid.