Related Experiment Video

Updated: Jun 21, 2025

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

36.4K

Blood protein assessment of leading incident diseases and mortality in the UK Biobank

Danni A Gadd1,2, Robert F Hillary1,2, Zhana Kuncheva1,3

  • 1Optima Partners, Edinburgh, UK.

Nature Aging
|July 10, 2024
PubMed

Insights

This study analyzed 1,468 Olink proteins in UK Biobank participants to identify associations with age-related diseases and mortality. ProteinScores showed promise in predicting disease onset, outperforming existing risk predictors for type 2 diabetes.

Area of Science:

  • Biochemistry and Molecular Biology
  • Genomics and Proteomics
  • Epidemiology and Public Health

Background:

  • The circulating proteome provides valuable insights into disease mechanisms.
  • Understanding proteomic contributions to age-related diseases is crucial for early detection and prevention.

Purpose of the Study:

  • To investigate associations between plasma protein levels and the incidence of 23 age-related diseases and mortality.
  • To develop and validate protein-based risk scores (ProteinScores) for predicting disease onset.
  • To compare the predictive performance of ProteinScores against established risk assessment tools.

Main Methods:

  • Analysis of 1,468 Olink protein levels in 47,600 UK Biobank participants.
  • Statistical association testing between protein levels and 21 incident age-related outcomes.
  • Development of ProteinScores using penalized Cox regression models.
  • Validation of ProteinScores in independent test sets and comparison with polygenic risk scores and clinical markers.

Main Results:

  • Identified 3,209 significant associations between 963 protein levels and 21 incident outcomes.
  • Six ProteinScores demonstrated improved prediction of 10-year disease onset beyond traditional risk factors.
  • The ProteinScore for type 2 diabetes outperformed both polygenic risk scores and HbA1c levels.

Conclusions:

  • Plasma proteomic profiling reveals early contributions to major age-related diseases.
  • ProteinScores offer a novel and effective tool for enhancing disease risk stratification.
  • The findings underscore the potential of the proteome in personalized medicine and disease prevention strategies.

More Related Videos

Preparation of Peripheral Blood Mononuclear Cell Pellets and Plasma from a Single Blood Draw at Clinical Trial Sites for Biomarker Analysis07:40

Preparation of Peripheral Blood Mononuclear Cell Pellets and Plasma from a Single Blood Draw at Clinical Trial Sites for Biomarker Analysis

Published on: March 20, 2021

16.7K
Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management05:35

Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management

Published on: January 19, 2024

765

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
74
Errors occurring during blood pressure monitoring01:25

Errors occurring during blood pressure monitoring

Blood pressure monitoring is a crucial clinical procedure in diagnosing and managing various cardiovascular conditions. Despite its significance, the accuracy of blood pressure measurements can be compromised by multiple factors, potentially leading to either falsely high or low readings. These inaccuracies are critical as they can significantly impact patient care. So, it is vital to understand these challenges deeply and adopt strategic approaches to minimize errors.
Several factors...
681
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
134
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
125