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Seagrass as a potential nutraceutical to decrease pro-inflammatory markers.

Vani Mathakala¹, Tejaswini Ullakula¹, Uma Maheswari Devi Palempalli²

¹Department of Applied Microbiology & Biochemistry, Sri Padmavati Mahila Visvavidyalayam (Women's University, Tirupati, 517 502, A.P, India.

BMC Complementary Medicine and Therapies

|July 10, 2024

Summary

This summary is machine-generated.

Seagrass extract, particularly from Halophila beccarii, shows significant anti-inflammatory effects by reducing key inflammatory markers. This nutraceutical agent holds promise for managing inflammation.

Keywords:

COX-2 Inducible nitric oxide synthase Inflammatory cytokines RAW 264.7 macrophages Seagrass Halophila beccarii

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Area of Science:

Marine Botany
Pharmacology
Biochemistry

Background:

Pro-inflammatory mediators like prostaglandin E2, nitric oxide, and TNF-α are central to inflammatory responses.
These mediators represent potential therapeutic targets for anti-inflammatory nutraceuticals.

Purpose of the Study:

To investigate the anti-inflammatory potential of seagrass extract.
To identify specific anti-inflammatory compounds within seagrass.

Main Methods:

Utilized LPS-induced RAW macrophages as an in-vitro model for inflammation.
Employed Western blot analysis and in-silico docking studies using Maestro 13.0 software.

Main Results:

Seagrass extract demonstrated anti-inflammatory activity by down-regulating pro-inflammatory markers: Cyclooxygenase-2 (COX-2), induced Nitric oxide synthase (iNOS), and prostaglandin E synthase-1 (PGES-1).
Phytochemical constituents including Isocoumarin, Hexadecanoic acid, Cis-9 Octadecenoic acid, 1,2 Benzene dicarboxylic acid, and beta-sitosterol were computationally docked with TNF-α, COX-2, iNOS, and PGES-1, validating the anti-inflammatory mechanism.

Conclusions:

The methanolic extract of the seagrass Halophila beccarii exhibits significant anti-inflammatory activity.
Halophila beccarii extract is identified as a promising nutraceutical agent for combating inflammation.