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Liposomal nano-carriers mediated targeting of liver disorders: mechanisms and applications

Mona M AbouSamra1

  • 1Pharmaceutical Technology Department, National Research Centre, Giza, Egypt.

Journal of Liposome Research
|July 11, 2024
PubMed

Insights

Liposomal nanocarriers offer innovative drug delivery for liver disorders. This review explores their mechanisms and therapeutic potential in treating conditions like cirrhosis and cancer, improving patient outcomes.

Area of Science:

  • Nanomedicine and Drug Delivery
  • Hepatology
  • Biotechnology

Background:

  • Liver disorders pose a major global health burden, with conventional treatments having limitations.
  • Innovative therapeutic strategies are crucial for managing diverse liver diseases effectively.
  • Liposomal nanocarriers represent a promising platform for targeted hepatic drug delivery.

Purpose of the Study:

  • To comprehensively review the mechanisms and applications of liposomal nanocarriers in liver disorder treatment.
  • To examine liposomal structure, composition, and targeting strategies (passive and active).
  • To explore the therapeutic potential of liposomes in liver cirrhosis, fibrosis, viral hepatitis, and hepatocellular carcinoma.

Main Methods:

  • Literature review of existing research on liposomal nanocarriers for liver diseases.
  • Analysis of liposomal targeting mechanisms, including passive and active approaches.
  • Synthesis of data on the application of liposomes in treating specific liver conditions.

Main Results:

  • Liposomal nanocarriers demonstrate significant potential for targeted drug delivery to the liver.
  • Both passive and active targeting strategies enhance liposomal accumulation in diseased liver tissue.
  • Liposomes show promise in managing liver cirrhosis, fibrosis, viral hepatitis, and hepatocellular carcinoma.

Conclusions:

  • Liposomal nanocarriers can enhance the efficacy and safety of liver disorder treatments.
  • Targeted delivery via liposomes offers improved patient outcomes and quality of life.
  • Further research and development in liposomal technology are warranted for advanced liver disease management.
Keywords:
Liver disordersactive targetingliposomal nanocarrierspassive targeting

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