Resveratrol Inhibits Nasopharyngeal Carcinoma (NPC) by Targeting the MAPK Signaling Pathway

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Yujuan Yi1, Bo Zhou1, Tengjun Man1

  • 1Institute (College) of Integrated Medicine, Dalian Medical University, Dalian, P.R. China.

Anti-Cancer Agents in Medicinal Chemistry
|July 11, 2024
PubMed
Abstract

Insights

Resveratrol shows potential against nasopharyngeal carcinoma by inhibiting cell proliferation and migration. It primarily targets the MAPK pathway, offering a promising natural alternative for cancer treatment.

Area of Science:

  • Oncology
  • Pharmacology
  • Natural Products Research

Background:

  • Conventional cancer treatments have limitations, increasing interest in plant-derived natural products.
  • Resveratrol exhibits antitumor effects in various cancers, but its role in nasopharyngeal carcinoma (NPC) is not well understood.

Purpose of the Study:

  • To investigate the anti-cancer effects and mechanisms of resveratrol on nasopharyngeal carcinoma.
  • Utilize experimental pharmacology, network pharmacology, and molecular docking for comprehensive analysis.

Main Methods:

  • Cell proliferation, migration, and invasion assays (CCK-8, scratch wound, Transwell).
  • Histological analysis (H&E, TUNEL staining) for apoptosis and morphology.
  • Network pharmacology and molecular docking to identify key pathways and targets.
  • Immunohistochemistry and Western blotting for pathway validation.

Main Results:

  • Resveratrol inhibited NPC cell proliferation, migration, and invasion, inducing apoptosis.
  • Network pharmacology identified the MAPK pathway as a primary target.
  • Western blotting confirmed resveratrol's inhibition of MAPK signaling.
  • Molecular docking supported multi-target interactions (MAPK, TP53, PIK3CA, SRC).

Conclusions:

  • Resveratrol demonstrates significant potential in inhibiting human nasopharyngeal carcinoma cells.
  • The primary mechanism involves targeting the MAPK signaling pathway.
  • Resveratrol represents a promising therapeutic candidate for nasopharyngeal carcinoma treatment.
Keywords:
MAPK signaling pathway.Nasopharyngeal carcinomaanti-proliferationapoptosisnetwork target predictionresveratrol

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