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Socioemotional Dysfunction From Temporal Lobe Involvement in Frontotemporal Dementia: A Preliminary Report.
Kelsey A Holiday1, Alexander Sheppard1, Youssef I Khattab1
1Veterans Administration Greater Los Angeles Healthcare System, Los Angeles (Holiday, Khattab, Chavez, Melrose, Mendez); Department of Neurology, University of California, Los Angeles (UCLA) (Holiday, Sheppard, Khattab, Chavez, Mendez); Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA (Melrose, Mendez).
Summary
Behavioral variant frontotemporal dementia (bvFTD) is linked to socioemotional changes stemming from right anterior temporal lobe atrophy. Early-onset Alzheimer's disease (EOAD) also shows socioemotional changes, associated with right parietal cortex atrophy.
Area of Science:
- Neuroscience
- Neurology
- Neuroimaging
Background:
- Behavioral variant frontotemporal dementia (bvFTD) is characterized by socioemotional changes, often attributed to frontal lobe dysfunction.
- Emerging evidence suggests a role for right anterior temporal lobe disease in these socioemotional alterations.
- The neuroanatomical underpinnings of socioemotional dysfunction in bvFTD and early-onset Alzheimer's disease (EOAD) require further investigation.
Purpose of the Study:
- To evaluate the relationship between regional brain atrophy and socioemotional changes in patients with bvFTD and EOAD.
- To identify specific brain regions associated with socioemotional dysfunction as measured by the Socioemotional Dysfunction Scale (SDS).
Main Methods:
- The study included 13 patients with bvFTD and 16 age-matched patients with EOAD.
- Tensor-based morphometric analysis of MRI images was used to assess regional brain volumes.
- Socioemotional Dysfunction Scale (SDS) scores were correlated with regional brain volumes.
Main Results:
- Patients with bvFTD exhibited higher SDS scores and smaller frontal regions compared to EOAD patients.
- SDS scores significantly correlated with lateral anterior temporal lobe (ATL) atrophy in bvFTD.
- In bvFTD, higher SDS scores were linked to atrophy in the lateral/right ATL and orbitofrontal cortex; in EOAD, higher SDS scores were associated with right parietal cortex atrophy.
Conclusions:
- Socioemotional changes in bvFTD originate from both orbitofrontal and prominent right/lateral ATL disease.
- Right parietal cortex involvement may contribute to socioemotional changes observed in EOAD.
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