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Updated: Jun 21, 2025
Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
Published on: November 27, 2019
Molecular Adsorbent Recirculating System in Acute Liver Failure
Khaled Alsabbagh Alchirazi1, Indira Bhavsar-Burke2, Hareem Syed3
1Department of Hospital Medicine, Cleveland Clinic Foundation, Cleveland, OH.
Abstract:
Acetaminophen (APAP) overdose is the most common cause of acute liver failure (ALF) in the United States. Liver transplantation (LT) is potentially lifesaving for patients with ALF, but its feasibility in clinical practice is limited. Liver assist devices, such as the Molecular Adsorbent Recirculating System (MARS), are used in some centers as a "bridge" to liver transplantation or as a means of liver recovery, but their role in the treatment of ALF is not well-defined. We present the case of a 44-year-old man with APAP-associated ALF who experienced hepatic recovery after treatment with MARS.
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