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Area of Science:

  • Biomedical Informatics
  • Computer Vision
  • Machine Learning

Background:

  • Human perception integrates multi-modal stimuli (acoustic, verbal, visual).
  • Multi-modal learning frameworks are effective for natural datasets but less explored in biomedicine.
  • Radiology data (images and reports) offers abundant unstructured multi-modal information.

Purpose of the Study:

  • To adapt and evaluate multi-modal and self-supervised learning frameworks for biomedical data, specifically chest radiograph classification.
  • To compare the effectiveness of multi-modal learning, self-supervised learning, and joint learning strategies for visual representation in this domain.

Main Methods:

  • Leveraging unstructured multi-modal data from radiology images and reports.
  • Implementing and comparing multi-modal learning, self-supervised learning, and a combination (joint learning).
  • Evaluating performance on downstream chest radiograph classification tasks, particularly with limited labeled data (1% and 10%).

Main Results:

  • Joint learning with multi-modal and self-supervised models outperformed self-supervised learning in limited labeled data settings (1% and 10%).
  • Joint learning performed comparably to multi-modal learning under these conditions.
  • Multi-modal learning demonstrated greater robustness on out-of-distribution datasets.

Conclusions:

  • Joint learning strategies effectively enhance visual representations for chest radiograph classification, especially when labeled data is scarce.
  • Multi-modal learning offers robustness, making it a valuable approach for biomedical applications.
  • The study provides insights into optimizing learning strategies for medical imaging analysis.