Related Experiment Video

Updated: Jun 21, 2025

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System
05:59

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System

Published on: October 20, 2023

2.4K

Efficacy of Melatonin Administration in Reducing Headaches in Children with Migraines without Sleep Disorders

Afshin Fayyazi1, Paria Abbasian2, Seyed Mohammad Sadegh Hosseini3

  • 1Department of pediatric neurology, Besat hospital, Hamadan University of Medical Sciences, Hamadan, Iran.

Iranian Journal of Child Neurology
|July 11, 2024
PubMed

Insights

Adding melatonin to propranolol treatment significantly reduced migraine frequency in children. This combination therapy also improved parent satisfaction without notable side effects, offering a promising approach for pediatric migraine management.

Area of Science:

  • Pediatric Neurology
  • Clinical Pharmacology

Background:

  • Migraine is a prevalent neurological disorder in children, impacting their quality of life.
  • Melatonin has shown potential in alleviating migraine headaches in some studies.

Purpose of the Study:

  • To evaluate the efficacy of melatonin as an adjunct therapy for reducing headache frequency in children with migraine without sleep disorders.

Main Methods:

  • A randomized controlled trial involving 55 children (aged 5-15) with migraine.
  • Intervention group received propranolol plus melatonin; control group received propranolol alone for three months.
  • Data on headache attacks, treatment response, disability, and side effects were collected at baseline and follow-up visits.

Main Results:

  • The intervention group showed a significant reduction in headache attack frequency compared to the control group (P=0.006).
  • A significantly higher proportion of patients in the intervention group achieved a good treatment response (p=0.023) and reported higher parental satisfaction (P=0.026).
  • No significant differences in headache-related disability or drug side effects were observed between groups.

Conclusions:

  • Adjunctive melatonin therapy to propranolol is effective in reducing migraine frequency in children without sleep disorders.
  • This combination therapy enhances treatment satisfaction among parents.
  • Melatonin appears to be a safe and effective addition to standard migraine treatment in pediatric patients.
Abstract

Keywords:
ChildrenMelatoninMigrainePreventionSleep Disorder

More Related Videos

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia04:34

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Published on: February 17, 2023

1.0K
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.2K

Related Concept Videos

Management of Insomnia01:19

Management of Insomnia

The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
243
Sedatives and Hypnotics Drugs: Miscellaneous Agents01:17

Sedatives and Hypnotics Drugs: Miscellaneous Agents

Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
166
Nightmares and Night Terrors01:18

Nightmares and Night Terrors

Nightmares and night terrors represent two distinct types of sleep disturbances that differ in timing, characteristics, and the sleeper's recall of the event. Nightmares are vivid, disturbing dreams that usually awaken the sleeper from REM sleep, a stage of sleep where brain activity is high, and dreams are most frequent. Upon awakening, individuals often have detailed recollections of their nightmares, which can include themes of threats to survival, security, or self-esteem.
Nightmares...
82
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
138