Association of retinal age gap with chronic kidney disease and subsequent cardiovascular disease sequelae: a cross-sectional and longitudinal study from the UK Biobank
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.The retinal age gap, a novel aging biomarker, is linked to increased risks of chronic kidney disease (CKD) and cardiovascular disease (CVD) complications. This finding highlights its potential for identifying high-risk individuals.
Area Of Science
- Ophthalmology
- Nephrology
- Cardiology
Background
- Chronic kidney disease (CKD) elevates cardiovascular disease (CVD) risk, particularly in older populations.
- Retinal age gap, a validated aging biomarker derived from fundus images, offers a novel perspective on biological aging.
Purpose Of The Study
- To investigate the association between retinal age gap and the prevalence and incidence of CKD.
- To examine the relationship between retinal age gap and subsequent CVD complications in individuals with CKD.
Main Methods
- A deep learning model predicted retinal age from 19,200 fundus images.
- Retinal age gap was calculated for 35,906 participants.
- Logistic and Cox proportional hazards regression models analyzed associations with CKD and CVD.
Main Results
- Each 1-year increase in retinal age gap correlated with a 2% higher risk of prevalent CKD (OR 1.02).
- Each 1-year increase in retinal age gap was linked to a 3% higher risk of incident CKD (HR 1.03).
- Each 1-year increase in retinal age gap was associated with a 10% higher risk of incident CVD in CKD patients (HR 1.10).
Conclusions
- Retinal age gap is independently associated with CKD prevalence and incidence.
- Retinal age gap predicts increased risk of CVD complications in CKD patients.
- Retinal age gap serves as a valuable biomarker for identifying individuals at high risk for CKD and associated CVD complications.
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
