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A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
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Hyperglycemic Patterns in Acute Stroke Patients.

Antigoni Fountouki1, Thomas Tegos2, Eleftheria Ztriva3

  • 1Nursing, International Hellenic University, Thessaloniki, GRC.

Cureus
|July 11, 2024
PubMed
Summary

Hyperglycemia in acute stroke patients often occurs at night or after meals, undetected by standard glucose tests. Continuous glucose monitoring reveals patterns, suggesting a need for intensive nighttime glucose management.

Keywords:
continuous glucose monitoringdiabetes type iiglucose managementglucose patternsstroke

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Area of Science:

  • Neurology
  • Endocrinology
  • Medical Technology

Background:

  • Hyperglycemia post-stroke exacerbates ischemic brain damage.
  • Effective glucose management is crucial for reducing stroke complications, mortality, and disability.

Purpose of the Study:

  • To investigate hyperglycemic patterns in acute stroke patients using continuous glucose monitoring (CGM).
  • To correlate admission glucose, mean glucose, and time in range (TIR) with observed hyperglycemic patterns.

Main Methods:

  • A prospective, non-interventional observational study of acute stroke patients.
  • Continuous glucose monitoring (CGM) was applied for 72 hours post-stroke symptom onset.
  • Statistical analysis included descriptive statistics, Kruskal-Wallis, and chi-squared tests.

Main Results:

  • Identified hyperglycemic patterns: nocturnal, morning, post-meal, or no specific pattern.
  • Patients with nocturnal/morning hyperglycemia had higher admission glucose (183 mg/dl) and lower TIR (37%).
  • Some patients without clear patterns showed either good glucose control or very high admission glucose with poor TIR.

Conclusions:

  • Conventional glucose monitoring may miss significant hyperglycemic tendencies in stroke patients.
  • Intensive glucose monitoring, especially during nighttime and dawn, is recommended.
  • Admission glucose levels may predict hyperglycemic patterns and inform patient care plans.