Survival outcome and prognostic factors of remnant gastric cancer: a propensity score-matched analysis
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View abstract on PubMed
Summary
This summary is machine-generated.Remnant gastric cancer (RGC) after initial gastric cancer (GC) shows similar survival outcomes to only primary GC (OPGC) after surgical resection. Prognostic factors for RGC are comparable to OPGC, suggesting RGC may be the same disease entity.
Area Of Science
- Oncology
- Surgical Gastroenterology
- Cancer Prognostics
Background
- Remnant gastric cancer (RGC) following initial gastric cancer (GC) lacks extensive survival and prognostic factor studies.
- The comparative prognosis between RGC and only primary gastric cancer (OPGC) remains debated.
Purpose Of The Study
- To compare survival outcomes between RGC and OPGC patients undergoing surgical resection.
- To identify independent prognostic factors for disease-specific survival (DSS) in RGC patients.
Main Methods
- Retrospective analysis of the SEER database (1988-2020) for GC patients.
- Propensity score matching (PSM) to balance baseline characteristics between RGC and OPGC groups.
- Kaplan-Meier analysis for overall survival (OS) and DSS; multivariable Cox analysis for prognostic factors.
Main Results
- No significant difference in OS or DSS was observed between RGC and OPGC groups post-PSM.
- 5-year and 10-year DSS rates were comparable between RGC and OPGC.
- Lower income, cardiac tumor location, deeper invasion (T3-4), higher grade (G3), and not receiving chemotherapy were independent risk factors for DSS in RGC.
Conclusions
- Post-GC RGC prognosis is comparable to OPGC after surgical resection.
- Prognostic factors for RGC align with those for OPGC.
- RGC may represent the same disease entity as OPGC, supporting consideration for curative resection in select patients.
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