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Related Experiment Videos

Upper airway response during bronchoprovocation and asthma attack.

C Shindoh, K Sekizawa, W Hida

    The American Review of Respiratory Disease
    |September 1, 1985
    PubMed
    Summary

    Laryngeal resistance (Rla) contributes to increased respiratory resistance in asthma patients, particularly during non-spasmodic periods and attacks. However, Rla does not significantly increase during bronchoprovocation challenges in asthmatics.

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    Area of Science:

    • Respiratory Physiology
    • Pulmonology
    • Medical Research

    Background:

    • Asthma involves complex airway changes affecting respiratory resistance.
    • Understanding the contribution of different airway segments to overall resistance is crucial for asthma management.

    Purpose of the Study:

    • To quantify laryngeal resistance (Rla), upper airway resistance (Ruaw), and lower respiratory resistance (Rlrs) in normal and asthmatic subjects.
    • To investigate the role of Rla in total respiratory resistance (Rrs) during spontaneous asthma attacks and bronchoprovocation.

    Main Methods:

    • Measured Rla using the low-frequency sound method.
    • Determined Ruaw and Rlrs via the 3-Hz forced oscillation technique with tracheal needle insertion.
    • Evaluated changes during methacholine/histamine provocation and spontaneous asthma attacks.

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    Main Results:

    • In normal subjects, Ruaw increased proportionally with Rlrs during provocation.
    • Asthmatic subjects exhibited higher baseline Ruaw than normal subjects.
    • In asthmatics, Ruaw remained unchanged despite increased Rlrs during provocation, indicating laryngeal involvement.
    • Rla decreased proportionally with Rrs after medication for asthma attacks.

    Conclusions:

    • Laryngeal resistance contributes to increased total respiratory resistance in asthmatics during non-spasmodic periods and spontaneous attacks.
    • The larynx appears less sensitive than the lower airways during bronchoprovocation challenges in asthma.