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Related Concept Videos

Teeth01:15

Teeth

373
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
373

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Related Experiment Video

Updated: Jun 21, 2025

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
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Data-driven dentistry: Computational revelations redefining pulp capping.

N Kiran Kumar1, V Swetha Geervani1, R S Mohan Kumar2

  • 1Department of Conservative Dentistry and Endodontics, Government Dental College and Research Institute, Bengaluru, Karnataka, India.

Journal of Conservative Dentistry and Endodontics
|July 11, 2024
PubMed
Summary
This summary is machine-generated.

Hesperidin shows strong potential as an MMP-9 inhibitor for pulpitis treatment. This study used computational methods to evaluate flavonoids, finding Hesperidin effective in reducing inflammation for dental pulp capping applications.

Keywords:
Flavonoidshesperidinin silicomatrix metalloproteinases-9pulp cappingpulpitis

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Area of Science:

  • Biochemistry
  • Computational Biology
  • Dental Research

Background:

  • Pulpal and periradicular diseases involve immune responses to microbiota, leading to inflammation.
  • Limited blood supply in dental pulp hinders natural healing.
  • Matrix metalloproteinase-9 (MMP-9) is a key pro-inflammatory mediator significantly correlated with pulpitis.

Purpose of the Study:

  • To computationally compare the anti-inflammatory effects of various flavonoids on MMP-9.
  • To identify potent MMP-9 inhibitors for potential use in pulp capping agents.

Main Methods:

  • In-silico molecular docking and dynamics simulations were performed on the human MMP-9 catalytic domain.
  • Flavonoids were sourced from the PubChem database and prepared for docking.
  • Binding free energies were calculated using MM-PBSA, with Chlorhexidine as a control.

Main Results:

  • Hesperidin exhibited high binding affinity to MMP-9, forming multiple hydrogen bonds.
  • Molecular dynamics simulations over 100 ns confirmed the stability of the MMP-9-Hesperidin complex.
  • MM-PBSA calculations indicated favorable binding free energies for Hesperidin.

Conclusions:

  • MMP-9 is critical in pulpitis prognosis.
  • Hesperidin is a potent MMP-9 inhibitor with potential for pulp capping agents.
  • Further in vivo studies are warranted to validate Hesperidin's efficacy.