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Updated: Jul 14, 2026

Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure
Published on: September 13, 2014
Arterial hypertension after liver transplantation
Insights
Arterial hypertension is a common risk factor after liver transplantation. 28% of patients developed new-onset hypertension, and factors like male sex, age, and waist circumference predicted intensified treatment needs.
Area of Science:
- Cardiology
- Hepatology
- Nephrology
Background:
- Arterial hypertension is a significant risk factor for cardiovascular disease.
- Liver transplantation (LT) recipients are susceptible to developing hypertension.
- Effective blood pressure (BP) management is crucial for post-LT outcomes.
Purpose of the Study:
- To identify post-LT patients without prior hypertension who meet criteria for new-onset arterial hypertension via 24-hour BP monitoring.
- To assess BP control in LT patients with pre-existing, treated arterial hypertension.
- To identify predictors of suboptimal BP control and the need for intensified antihypertensive treatment.
Main Methods:
- Prospective analysis of 88 liver transplant recipients.
- Utilized 24-hour ambulatory BP monitoring.
- Collected data on patient demographics, medical history, and physical measurements.
Main Results:
- De novo arterial hypertension was diagnosed in 28% of post-LT patients.
- Hypertonic fundus oculi changes predicted suboptimally controlled hypertension (OR 5.13, p=0.0279).
- Male sex (OR 3.18, p=0.0311), age (OR 1.33, p=0.0153), and waist circumference (OR 4.35, p=0.0418) predicted the need for intensified antihypertensive treatment.
Conclusions:
- A significant proportion of liver transplant recipients develop new-onset arterial hypertension.
- Fundus examination can serve as a surrogate marker for suboptimal hypertension control.
- Clinical factors including male sex, age, and waist circumference warrant increased vigilance for poorly controlled BP in LT patients.
Abstract:
One of the most prevalent influenceable risk factors for poor cardiovascular outcome is arterial hypertension.This is a prospective analysis of liver transplant recipients in which 24-hour blood pressure (BP) measurement was performed. The primary aim was to identify post-LT (liver transplantation) patients without a history of arterial hypertension who meet the criteria for arterial hypertension using 24-hour BP monitoring. Secondary objectives were to determine how many patients with known treated arterial hypertension had suboptimal BP control. The group included 88 patients (men, 52.3%, history of arterial hypertension group: n=56, no history of arterial hypertension group: n=32) with an average age at the time of measurement of 62.4 years±11. The average time since LT at the time of measurement was 45.2 months. De novo arterial hypertension using 24-hour BP monitoring was diagnosed in 28%. Hypertonic changes in the fundus oculi were confirmed as predictor for suboptimally controlled hypertension [OR 5,1265, p=0.0279]. On the other hand, male sex [OR 3.1840, p=0.0311], together with age [OR 1.3347, p=0.0153] and waist circumference [OR 4.3490, p=0.0418] predicted the need of intensification of antihypertensive treatment. Male sex, age and waist circumference should increase the index of suspicion and lead to zoom-in on a possibility of poorly controlled blood pressure. Where automated blood pressure monitoring is unavailable, regular examination of the fundus could serve as an available surrogate marker of suboptimally controlled arterial hypertension (Tab.6, Fig. 1, Ref. 36). Text in PDF www.elis.sk Keywords: liver transplantation, arterial hypertension, automated blood pressure monitoring.
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