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[Primperan and gastroesophageal reflux. Review of the literature]
Abstract:
After reviewing its mechanism of action, the author summarises the action of Primperan in gastro-oesophageal reflux. Various studies have shown that the intravenous or oral administration of a single dose of Primperan induces an increase in the tone of the inferior oesophageal sphincter and an acceleration of gastric emptying in patients with gastro-oesophageal reflux. A dose of at least 10 mg is required. Long term Primperan treatment, at a dose of 40 mg/day in 4 doses, before each meal and at bedtime, significantly reduces the symptoms of gastro-oesophageal reflux and the consumption of antacids.
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