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Pulse amplitude and quality

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Pulse amplitude is a crucial indicator of cardiac health because it provides valuable insights into the strength of left ventricular contractions and the overall uniformity of blood circulation within the vasculature. The strength of the pulse is directly related to the force with which the heart contracts and the volume of blood being pumped.
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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

Pulse

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When the heart pumps blood out, arterial elastic fibers play a crucial role in sustaining a high-pressure gradient. They expand to accommodate the received blood and then recoil - a process known as the pulse that can be either manually palpated or electronically quantified. Despite a reduction in its effect with increased distance from the heart, elements of the pulse's systolic and diastolic components persist, observable even at the arteriole level.
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Related Experiment Video

Updated: Jun 21, 2025

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

Differences in Systemic Pulse Waveform Between Individuals With Glaucoma, Glaucoma Suspects, and Healthy Controls.

Hongli Yang¹, Grant Cull¹, Mingrui Yang²

¹Discoveries in Sight Research Laboratories, Devers Eye Institute, Legacy Health, Portland, Oregon, United States.

Investigative Ophthalmology & Visual Science

|July 11, 2024

Summary

Systemic blood flow pulse patterns differ in glaucoma patients and suspects compared to healthy individuals, indicating potential arterial stiffness and compromised circulation. This finding highlights a link between ocular disease and broader vascular health.

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Area of Science:

Ophthalmology
Cardiovascular Research
Biomedical Engineering

Background:

Glaucoma is hypothesized to involve compromised ocular circulation linked to systemic changes.
Understanding systemic vascular patterns in glaucoma is crucial for comprehensive patient care.

Purpose of the Study:

To investigate differences in systemic blood flow pulse waveform patterns among individuals with glaucoma (GL), glaucoma suspects (GLS), and healthy controls (HC).
To determine if systemic vascular markers correlate with glaucoma severity.

Main Methods:

Systemic pulsatile blood pressure waveforms were recorded using finger-cuff plethysmography in 35 GL, 67 GLS, and 44 HC individuals.
Waveform parameters were extracted and compared between groups using generalized estimating equation models.
Correlations with visual field mean deviation (MDlin) and retinal nerve fiber layer thickness (RNFLT) were analyzed.

Main Results:

Healthy controls exhibited significantly lower average blood pressure compared to glaucoma and suspect groups (P < 0.0001).
Vascular resistance parameters were elevated in both glaucoma and suspect groups versus controls.
These parameters correlated with RNFLT and MDlin, suggesting a link to disease severity.

Conclusions:

Systemic pulsatile waveform shapes differ between glaucoma/suspects and healthy individuals.
More rapid blood pressure changes in glaucoma patients suggest increased arterial stiffness.
These findings support a connection between systemic vascular health and glaucoma.