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Updated: Jun 21, 2025

Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma
Published on: November 19, 2019
Unveiling the Culprit: IL17 Signaling in the Pancreatic Epithelium Drives Tumorigenesis
Kyoung Eun Lee1,2, Marina Pasca di Magliano2,3,4
1Department of Pharmacology, University of Michigan, Ann Arbor, Michigan.
Abstract:
IL17 signaling promotes pancreatic cancer development, yet the cell compartment responsible for the protumorigenic function of IL17 has not been defined. In this article, Castro-Pando and colleagues demonstrate that IL17/IL17 receptor A signaling in the pancreatic epithelium is critical for pancreatic cancer initiation and for establishing immunosuppression, whereas its signaling in the immune compartment is dispensable. This work provides an important mechanistic insight on the role of IL17 signaling and identifies a potential new immune checkpoint as a target in pancreatic cancer. See related article by Castro-Pando et al., p. 1170.
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