Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Master Transcription Regulators

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Glial Cell Development and Function in the Zebrafish Central Nervous System.

Cold Spring Harbor perspectives in biology·2024

Same author

Synaptic input and Ca<sup>2+</sup> activity in zebrafish oligodendrocyte precursor cells contribute to myelin sheath formation.

Nature neuroscience·2024

Same author

Myelination-independent functions of oligodendrocyte precursor cells in health and disease.

Nature neuroscience·2023

Same author

CaBLAM! A high-contrast bioluminescent Ca<sup>2+</sup> indicator derived from an engineered <i>Oplophorus gracilirostris</i> luciferase.

bioRxiv : the preprint server for biology·2023

Same author

Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling.

Nature neuroscience·2022

Same author

Functionally distinct subgroups of oligodendrocyte precursor cells integrate neural activity and execute myelin formation.

Nature neuroscience·2020

Search research articles

Related Experiment Video

Updated: Jun 21, 2025

Generation of Oligodendrocytes and Oligodendrocyte-Conditioned Medium for Co-Culture Experiments

Generation of Oligodendrocytes and Oligodendrocyte-Conditioned Medium for Co-Culture Experiments

Published on: February 9, 2020

A new gatekeeper to control oligodendrogenesis.

¹Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, United Kingdom.

|July 11, 2024

Summary

Researchers identified a new marker for a specific oligodendrocyte precursor cell (OPC) subpopulation. This discovery sheds light on OPC diversity and its role in controlling oligodendrogenesis and myelination.

Area of Science:

Neuroscience
Cell Biology
Developmental Biology

Background:

Oligodendrocyte precursor cells (OPCs) are crucial for central nervous system development and repair.
The heterogeneity and specific functions of OPC subpopulations remain incompletely understood.
Understanding OPC diversity is key to deciphering mechanisms of oligodendrogenesis and myelination.

Purpose of the Study:

To investigate the diversity within OPC populations.
To identify novel markers for specific OPC subpopulations.
To elucidate the functional role of identified OPC subpopulations in oligodendrogenesis and myelination.

Main Methods:

Utilized single-cell RNA sequencing to analyze OPC heterogeneity.
Developed and applied a novel antibody-based marker to identify a specific OPC subpopulation.

More Related Videos

Preparation of Rat Oligodendrocyte Progenitor Cultures and Quantification of Oligodendrogenesis Using Dual-infrared Fluorescence Scanning

Preparation of Rat Oligodendrocyte Progenitor Cultures and Quantification of Oligodendrogenesis Using Dual-infrared Fluorescence Scanning

Published on: February 17, 2016

Generation of Human Neurons and Oligodendrocytes from Pluripotent Stem Cells for Modeling Neuron-Oligodendrocyte Interactions

Generation of Human Neurons and Oligodendrocytes from Pluripotent Stem Cells for Modeling Neuron-Oligodendrocyte Interactions

Published on: November 9, 2020

Related Experiment Videos

Last Updated: Jun 21, 2025

Generation of Oligodendrocytes and Oligodendrocyte-Conditioned Medium for Co-Culture Experiments

Generation of Oligodendrocytes and Oligodendrocyte-Conditioned Medium for Co-Culture Experiments

Published on: February 9, 2020

Preparation of Rat Oligodendrocyte Progenitor Cultures and Quantification of Oligodendrogenesis Using Dual-infrared Fluorescence Scanning

Preparation of Rat Oligodendrocyte Progenitor Cultures and Quantification of Oligodendrogenesis Using Dual-infrared Fluorescence Scanning

Published on: February 17, 2016

Generation of Human Neurons and Oligodendrocytes from Pluripotent Stem Cells for Modeling Neuron-Oligodendrocyte Interactions

Generation of Human Neurons and Oligodendrocytes from Pluripotent Stem Cells for Modeling Neuron-Oligodendrocyte Interactions

Published on: November 9, 2020

Performed functional assays to assess the impact of this subpopulation on oligodendrogenesis and myelination in vitro and in vivo.

Main Results:

Identified a novel marker that defines a distinct OPC subpopulation.
Demonstrated that this OPC subpopulation plays a critical role in regulating the timing and extent of oligodendrogenesis.
Showed that this subpopulation is essential for efficient myelination of axons.

Conclusions:

The study reveals significant heterogeneity among OPCs, challenging previous assumptions.
A newly identified OPC subpopulation, marked by a novel marker, actively controls oligodendrogenesis and myelination.
This finding provides new avenues for understanding and potentially manipulating myelin repair processes.