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The incidence and type of reactions to plain and adsorbed DTP vaccines
Insights
Plain diphtheria-tetanus-pertussis vaccine showed fewer local reactions than adsorbed vaccine, with no significant difference in general reactions. Both vaccine types were generally safe for routine childhood immunization.
Area of Science:
- Immunology
- Vaccinology
- Pediatrics
Background:
- Diphtheria-tetanus-pertussis (DTP) vaccines are crucial for routine childhood immunization.
- Understanding reaction profiles of different DTP vaccine formulations is important for safety and adherence.
Purpose of the Study:
- To compare the incidence and types of reactions between plain and adsorbed diphtheria-tetanus-pertussis vaccines.
- To evaluate the safety of DTP vaccines in infants during routine immunization.
Main Methods:
- A blind controlled prospective study involving 2041 vaccinations in 1075 infants.
- Recording and comparing general and local reactions following administration of plain and adsorbed DTP vaccines.
Main Results:
- No significant difference in the total incidence or type of general reactions (e.g., irritability, fever) between plain and adsorbed DTP vaccines.
- Local reactions were significantly less frequent following administration of the plain DTP vaccine compared to the adsorbed vaccine.
- Severe adverse events like hyporesponsiveness, collapse, and convulsions were rare in both groups.
Conclusions:
- Plain DTP vaccine may be preferred over adsorbed DTP vaccine due to a lower incidence of local reactions.
- Both plain and adsorbed DTP vaccines demonstrate a favorable safety profile for routine infant immunization, with minimal severe adverse events.
Abstract:
The incidence and type of reactions after administration of plain and adsorbed diphtheria-tetanus-pertussis vaccine were recorded in a blind controlled prospective study of 2041 vaccinations in 1075 infants receiving routine childhood immunization. There was no significant difference in the total incidence or type of general reactions after plain and adsorbed vaccine, but local reactions were significantly less frequent after plain vaccine. General reactions were recorded after 41.5% of vaccinations with plain vaccine and after 40.8% of vaccinations with adsorbed vaccine. Local reactions were reported in 66.7% and 76.5% of recipients respectively. The most commonly reported systemic reactions were irritability and fever. Three recipients of plain vaccine and one of adsorbed vaccine suffered hyporesponsiveness or collapse. One recipient of each vaccine suffered a convulsion. No persisting sequelae were recorded.