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Updated: Jun 21, 2025

Biomechanical Changes Related to Low Back Pain: An Innovative Tool for Movement Pattern Assessment and Treatment Evaluation in Rehabilitation
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Lipid levels and low back pain risk: A two-sample mendelian randomization study.

Jinfeng Luo1, Yuling Xing2, Fangzhou Li1

  • 1Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, P.R. China.

Plos One
|July 11, 2024
PubMed
Summary

This study used Mendelian randomization to investigate lipid levels and low back pain (LBP). Increased high-density lipoprotein cholesterol (HDL-C) was causally linked to reduced LBP risk in European populations.

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Area of Science:

  • Genetics
  • Epidemiology
  • Metabolic Health

Background:

  • Observational studies on lipid levels and low back pain (LBP) have yielded conflicting results.
  • A Mendelian randomization (MR) approach was employed to investigate potential causal links.

Purpose of the Study:

  • To determine the causal relationship between lipid profiles and the risk of LBP.
  • To leverage genetic variants as instrumental variables for lipid levels and LBP.

Main Methods:

  • A two-sample MR study utilizing publicly available data.
  • Genetic instrumental variables for high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) were identified.
  • Multiple MR methods including IVW, weighted median, MR-Egger, MR-RAPS, and MR-PRESSO were applied.

Main Results:

  • Increased HDL-C levels showed a significant inverse causal association with LBP risk in European populations across various MR analyses (e.g., IVW OR=0.923, P=0.0323).
  • No significant causal relationship was detected between LDL-C or TG levels and LBP risk.

Conclusions:

  • This MR study provides evidence for a causal link between lipid levels and LBP.
  • Further research is warranted to explore the specific mechanisms underlying the association between HDL-C and LBP.