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[The fibroblast].

M T Pieraggi, H Bouissou, C Angelier

    Annales De Pathologie
    |January 1, 1985
    PubMed
    Summary
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    Fibroblasts, key connective tissue cells, change morphology and function with age, impacting interstitial structures and cholesterol metabolism. Stimuli can activate quiescent fibroblasts into secretory cells or myofibroblasts.

    Area of Science:

    • Connective tissue biology
    • Cellular morphology
    • Extracellular matrix dynamics

    Background:

    • Fibroblasts are crucial connective tissue cells responsible for secreting and maintaining interstitial components.
    • These cells also play a role in cholesterol low-density lipoprotein (LDL) metabolism.
    • Fibroblast morphology varies significantly with age and physiological state.

    Purpose of the Study:

    • To describe the morphological and functional changes of fibroblasts throughout aging.
    • To understand how fibroblasts respond to various activating stimuli.
    • To elucidate the transformation of fibroblasts into myofibroblasts.

    Main Methods:

    • Histological examination of fibroblast morphology across different age groups (young, adult, old).

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  • Analysis of cellular organelles, cytoskeleton, and extracellular matrix interactions.
  • Observation of fibroblast response to activating stimuli.

    • Main Results:

    • Young fibroblasts are active secretory cells with well-developed organelles and close collagen contact.
    • Adult fibroblasts show similar characteristics but with reduced endoplasmic reticulum.
    • Old fibroblasts become quiescent, flattened cells with poor organelle development and altered cytoskeleton.
    • Stimulation can transform fibroblasts into highly secretory cells or myofibroblasts containing myofilaments.

    Conclusions:

    • Fibroblast morphology and function are dynamic and age-dependent.
    • Environmental stimuli can induce significant fibroblast activation and differentiation.
    • Understanding fibroblast plasticity is key to comprehending connective tissue maintenance and disease.