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Related Experiment Videos

Atracurium and intraocular pressure.

D F Murphy, P Eustace, A Unwin

    The British Journal of Ophthalmology
    |September 1, 1985
    PubMed
    Summary

    Atracurium significantly reduces intraocular pressure more than pancuronium during cataract surgery. However, tracheal intubation still increases intraocular pressure, regardless of the muscle relaxant used.

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    Area of Science:

    • Anesthesiology
    • Ophthalmology

    Background:

    • Intraocular pressure (IOP) management is critical during ophthalmic surgery.
    • Neuromuscular blocking agents are used to facilitate tracheal intubation and surgical conditions.
    • Pancuronium is a commonly used muscle relaxant, but its effects on IOP require comparison with newer agents.

    Purpose of the Study:

    • To compare the effects of atracurium and pancuronium on intraocular pressure in patients undergoing cataract surgery.
    • To evaluate the impact of tracheal intubation on intraocular pressure following administration of these muscle relaxants.

    Main Methods:

    • A randomized controlled trial was conducted.
    • Intraocular pressure was measured in patients before and at several time points after administration of atracurium or pancuronium.
    • Measurements were also taken after tracheal intubation.

    Main Results:

    • Atracurium demonstrated a significantly greater decrease in intraocular pressure compared to pancuronium.
    • Tracheal intubation led to a significant increase in intraocular pressure compared to the post-induction measurement, irrespective of the muscle relaxant used.

    Conclusions:

    • Atracurium is a viable alternative to pancuronium for ophthalmic surgery regarding its effect on intraocular pressure.
    • Neither atracurium nor pancuronium prevents the transient increase in intraocular pressure associated with tracheal intubation.

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